K+ channels lacking the 'tetramerization' domain: implications for pore structure

@article{Kobertz1999KCL,
  title={K+ channels lacking the 'tetramerization' domain: implications for pore structure},
  author={William R Kobertz and Christopher Miller},
  journal={Nature Structural Biology},
  year={1999},
  volume={6},
  pages={1122-1125}
}
The difficulty of obtaining high-resolution structures of integral membrane proteins has been a frustrating barrier to understanding the membrane-based functions of living cells. The mere handful of such structures stands out in dismal contrast to the cornucopia of water-soluble proteins comprehensible at the atomic level. Nevertheless, crystallographically tractable preparations of aqueous domains of membrane proteins have provided molecular insight into phenomena as varied as chemotaxis… CONTINUE READING
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