K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.

@article{Clancy2003KCS,
  title={K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.},
  author={Colleen E. Clancy and Junko Kurokawa and Michihiro Tateyama and Xander H T Wehrens and Robert Kass},
  journal={Annual review of pharmacology and toxicology},
  year={2003},
  volume={43},
  pages={
          441-61
        }
}
  • Colleen E. Clancy, Junko Kurokawa, +2 authors Robert Kass
  • Published in
    Annual review of pharmacology…
    2003
  • Medicine
  • Pharmacological intervention, often for the purpose of treating syndromes unrelated to cardiac disease, can increase the vulnerability of some patients to life-threatening rhythm disturbances. This may be due to an underlying propensity stemming from genetic defects or polymorphisms, or structural abnormalities that provide a substrate allowing for the initiation of arrhythmic triggers. A number of pharmacological agents that have proven useful in the treatment of allergic reactions… CONTINUE READING

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