K+ channel facilitation of exocytosis by dynamic interaction with syntaxin.

@article{SingerLahat2007KCF,
  title={K+ channel facilitation of exocytosis by dynamic interaction with syntaxin.},
  author={Dafna Singer-Lahat and Anton Sheinin and D. V. Chikvashvili and Sharon Tsuk and Dafna Greitzer and Reut Friedrich and Lori Feinshreiber and Uri Ashery and Morris Benveniste and Edwin S Levitan and Ilana Lotan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 7},
  pages={1651-8}
}
Kv channels inhibit release indirectly by hyperpolarizing membrane potential, but the significance of Kv channel interaction with the secretory apparatus is not known. The Kv2.1 channel is commonly expressed in the soma and dendrites of neurons, where it could influence the release of neuropeptides and neurotrophins, and in neuroendocrine cells, where it could influence hormone release. Here we show that Kv2.1 channels increase dense-core vesicle (DCV)-mediated release after elevation of… CONTINUE READING

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