K+ channel KVLQT1 located in the basolateral membrane of distal colonic epithelium is not essential for activating Cl- secretion.

@article{Liao2005KCK,
  title={K+ channel KVLQT1 located in the basolateral membrane of distal colonic epithelium is not essential for activating Cl- secretion.},
  author={Tianjiang Liao and Ling Wang and Susan Troutman Halm and Luo Lu and Robert E. W. Fyffe and Dan R. Halm},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 3},
  pages={C564-75}
}
The cellular mechanism for Cl(-) and K(+) secretion in the colonic epithelium requires K(+) channels in the basolateral and apical membranes. Colonic mucosa from guinea pig and rat were fixed, sectioned, and then probed with antibodies to the K(+) channel proteins K(V)LQT1 (Kcnq1) and minK-related peptide 2 (MiRP2, Kcne3). Immunofluorescence labeling for Kcnq1 was most prominent in the lateral membrane of crypt cells in rat colon. The guinea pig distal colon had distinct lateral membrane… CONTINUE READING

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