K+, MG2+-aspartate (KMg-ASP)--mediated prevention of isoproterenol(ISO)-induced metabolic changes in the myocardium.


Isoproterenol (ISO) in a single dose of 7.5 mg/kg b.w. i.v was found to produce alterations of cardiac metabolism in dogs. After 2 h, high energy phosphate stores and glycogen were reduced, whereas the levels of lactate, pyruvate, the lactate/pyruvate ratio and myofibrillar ATPase activity were elevated. Ca2+ -accumulation by sarcoplasmic reticulum (SR) and… (More)


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