K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.

@article{Ploug2008KATPCE,
  title={K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.},
  author={Kenneth Beri Ploug and Lauren Julia Boni and Michael Baun and Anders Hay-Schmidt and Jes Olesen and Inger Jansen-Olesen},
  journal={British journal of pharmacology},
  year={2008},
  volume={154 1},
  pages={72-81}
}
BACKGROUND AND PURPOSE Dilatation of cerebral and dural arteries causes a throbbing, migraine-like pain, indicating that these structures are involved in migraine. Clinical trials suggest that adenosine 5'-triphosphate-sensitive K(+) (K(ATP)) channel opening may cause migraine by dilatating intracranial arteries, including the middle meningeal artery (MMA). We studied the K(ATP) channel expression profile in rat MMA and examined the potential inhibitory effects of the K(ATP) channel blocker PNU… CONTINUE READING