K(+)-dependent composite gating of the yeast K(+) channel, Tok1.

  title={K(+)-dependent composite gating of the yeast K(+) channel, Tok1.},
  author={Stephen H. Loukin and Yoshiro Saimi},
  journal={Biophysical journal},
  volume={77 6},
TOK1 encodes an outwardly rectifying K(+) channel in the plasma membrane of the budding yeast Saccharomyces cerevisiae. It is capable of dwelling in two kinetically distinct impermeable states, a near-instantaneously activating R state and a set of related delayed activating C states (formerly called C(2) and C(1), respectively). Dwell in the R state is dependent on membrane potential and both internal and external K(+) in a manner consistent with the K(+) electrochemical potential being its… CONTINUE READING

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