Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.

Abstract

We have analysed the genomic structure and transcriptional activity of a 2.3-Mb genomic sequence in the juxtacentromeric region of human chromosome 21. Our work shows that this region comprises two different chromosome domains. The 1.5-Mb proximal domain: (i) is a patchwork of chromosome duplications; (ii) shares sequence similarity with several chromosomes… (More)

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Cite this paper

@article{Brun2003JuxtacentromericRO, title={Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms.}, author={Marie-Elisabeth Brun and Myriam Ruault and Mario Ventura and G{\'e}rard Roizes and Albertina De Sario}, journal={Gene}, year={2003}, volume={312}, pages={41-50} }