Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.

@article{Jullienne2014JuvenileTB,
  title={Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation.},
  author={Amandine Jullienne and Jill M. Roberts and Viorela Pop and M Paul Murphy and Elizabeth Head and Gregory J Bix and J{\'e}r{\^o}me Badaut},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2014},
  volume={34 10},
  pages={
          1637-45
        }
}
In our juvenile traumatic brain injury (jTBI) model, emergence of cognitive dysfunctions was observed up to 6 months after trauma. Here we hypothesize that early brain injury induces changes in the neurovascular unit (NVU) that would be associated with amyloid-beta (Aβ) accumulation. We investigated NVU changes for up to 6 months in a rat jTBI model, with a focus on the efflux protein P-glycoprotein (P-gp) and on the basement membrane proteins perlecan and fibronectin, all known to be involved… CONTINUE READING
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