Juvenile rheumatoid arthritis: linkage to HLA demonstrated by allele sharing in affected sibpairs.

@article{Prahalad2000JuvenileRA,
  title={Juvenile rheumatoid arthritis: linkage to HLA demonstrated by allele sharing in affected sibpairs.},
  author={Sampath Prahalad and Mary H. Ryan and Edith S. Shear and Susan D. Thompson and Edward H. Giannini and David N. Glass},
  journal={Arthritis and rheumatism},
  year={2000},
  volume={43 10},
  pages={2335-8}
}
OBJECTIVE To test for linkage between the HLA region and juvenile rheumatoid arthritis (JRA), with stratification by onset and course types, in a cohort of affected sibling pairs (ASPs). METHODS Eighty pairs of siblings with JRA who were registered with the Research Registry for JRA ASPs (sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases) were typed for HLA-DR. The observed ratio of sharing of none, one, or both parental DR alleles was compared against the… CONTINUE READING
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