Juvenile myelomonocytic leukemia and Noonan syndrome.

  title={Juvenile myelomonocytic leukemia and Noonan syndrome.},
  author={Karen L M Choong and Melvin H. Freedman and David Chitayat and Edmond N. Kelly and Gwendolyn Taylor and Alvin Zipursky},
  journal={Journal of pediatric hematology/oncology},
  volume={21 6},
A case of juvenile myelomonocytic leukemia (JMML, previously referred to as JCML) in a neonate with Noonan syndrome (NS) is described. The boy presented with bilateral congenital hydrothoraces, nonimmune hydrops, dysmorphic facies, persistent thrombocytopenia, and leukocytosis. The diagnosis of JMML was made on bone marrow cell culture studies. Review of the literature reveals an unusual preponderance of hematologic malignancies, in particular JMML, among patients with NS. Of 40 NS patients… CONTINUE READING
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