Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system.

@article{Henrich2003JuvenileHP,
  title={Juvenile hormone potentiates ecdysone receptor-dependent transcription in a mammalian cell culture system.},
  author={Vincent C. Henrich and Edina L. Burns and David P Yelverton and Erin Christensen and Cary Weinberger},
  journal={Insect biochemistry and molecular biology},
  year={2003},
  volume={33 12},
  pages={1239-47}
}
Insect development is guided by the combined actions of ecdysteroids and juvenile hormones (JHs). The transcriptional effects of ecdysteroids are mediated by a protein complex consisting of the ecdysone receptor (EcR) and its heterodimeric partner, Ultraspiracle (USP), but a corresponding JH receptor has not been defined conclusively. Given that the EcR ligand binding domain (LBD) is similar to that of the JH-responsive rat farnesoid-X-activated receptor (FXR), we sought to define experimental… CONTINUE READING
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