Juvenile dermatitis herpetiformis and chronic acquired bullous disease in children

@article{Thune1978JuvenileDH,
  title={Juvenile dermatitis herpetiformis and chronic acquired bullous disease in children},
  author={Per O. Thune and Gunnar Husby and T. Eeg Larsen and B. Solheim and J. Ek},
  journal={Clinical and Experimental Dermatology},
  year={1978},
  volume={3}
}
  • P. Thune, G. Husby, J. Ek
  • Published 1 September 1978
  • Medicine, Biology
  • Clinical and Experimental Dermatology
Eight children with chronic acquired bullous disease were studied by direct immunofluorescence. Multiple jejunal biopsies were examined as well as tissue antigens (HLA‐andthcDRw3 B cell allo‐antigen). Juvenile dermatitis herpetiformis (JDH) was diagnosed in seven patients and chronic bullous disease of childhood (CBDC) in one. The use of these different laboratory techniques may make it possible to differentiate more clearly between the different chronic acquired bullous diseases seen in… 
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Fifty seven children with dermatitis herpetiformis, 18 from Finland and 39 from Hungary, were studied and symptoms suggesting small intestinal disease were rare but in 35 (61%) of the children subtotal villous atrophy and in 16 (28%) partial villousatrophy were found.
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TLDR
Fifty seven children with dermatitis herpetiformis, 18 from Finland and 39 from Hungary, were studied and symptoms suggesting small intestinal disease were rare but in 35 (61%) of the children subtotal villous atrophy and in 16 (28%) partial villousatrophy were found.
Pemphigoid in Children
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Pemphigoid is an autolmmune blistering disease that is rare in childhood and has no association with malignancy, which is a controversial and presumably incorrectly assumed association in the adult disease.
Dermatitis herpetiformis: jejunal findings and skin response to gluten free diet.
TLDR
It is confirmed that most children with dermatitis herpetiformis have jejunal villous atrophy, though they rarely have gastrointestinal symptoms, and that a gluten free diet helps the damagedJejunal mucosa to recover and controls the rash even in those children who do not have an abnormal jeJunal biopsy.
The value of immunofluorescence techniques in the diagnosis of bullous disorders: a review
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If the initial IMF findings are negative and the bullous disease is evolving or changing its clinical appearance, both histopathology and IMF tests should be repeated at serial intervals.
CHRONIC BULLOUS DISEASE OF CHILDHOOD—ASPECTS OF MANAGEMENT *
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The management of chronic bullous disease of childhood is discussed and the use of sulphapyridine or dapsone in preference to oral corticosteroids is advocated.

References

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TLDR
Immunofluorescence has been valuable as a diagnostic aid in clarifying the relationship of dermatitis herpetiformis and bullous pemphigoid to benign chronic bullous dermatosis of childhood, which appears to be a distinct and separate entity.
Juvenile dermatitis herpetiformis versus "benign chronic bullous dermatosis of childhood." Are these immunologic diseases?
TLDR
Seven cases of juvenile dermatitis herpetiformis have been investigated and the question arises whether any immunologically negative cases of "benign chronic bullous dermatosis of childhood" actually exist.
Childhood bullous dermatitis herpetiformis. Negative immunofluorescent tests.
TLDR
Indirect immunofluorescent staining revealed that the sera of six patients with active childhood bullous dermatitis herpetiformis were negative for basement-membrane zone or "pemphigoid" antibodies, and this disease appears to be immunologically distinct from bullous pemphIGoid as it occurs in the adult.
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TLDR
This work reports the first case known to us in which a linear bank of IgA (but no lgG or lgM) and complement was found at the epidermal basal lamina as demonstrated by immunofluorescence studies.
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TLDR
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TLDR
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JUVENILE DERMATITIS HERPETIFORMIS IN THE LIGHT OF IMMUNOFLUORESCENCE STUDIES
TLDR
Eight cases of juvenile dermatitis herpetiformis were investigated by direct and indirect IF methods with anti‐IgG and anti-IgA conjugates with mixed results.
Clinical response of dermatitis herpetiformis skin lesions to a gluten‐free diet
TLDR
Patients with dermatitis herpetiformis have been studied prospectively for 2 years to assess the effect of a gluten‐free diet (GFD) on control of the skin lesions and many of the latter group exhibited variation in their drug dose requirements during the period of study.
Histocompatibility antigens and dermatitis herpetiformis with special reference to jejunal abnormalities and acetylator phenotype
TLDR
The frequency of HL‐A8 was about equal in patients in whom DH was associated with jejunal abnormalities and in those in whom it was not, and when correlated with rate of acetylation, there was no significant difference in the occurrence of various HL-A antigens.
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TLDR
A 6-year-old boy was sent for consultation to the authors' clinic with a history of bullae on the scalp, on the face, around the nose, behind the ears, followed by lesions on the scrotum and in the inguinal regions, but on first examination no bullae could be detected on the skin.
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