Junin virus infection of Callithrix jacchus: pathologic features.

  title={Junin virus infection of Callithrix jacchus: pathologic features.},
  author={P. H. Gonz{\'a}lez and Rub{\'e}n P. Laguens and M. J. Frigerio and M. A. Calello and Mercedes C. Weissenbacher},
  journal={The American journal of tropical medicine and hygiene},
  volume={32 2},
Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by… CONTINUE READING