Junctions as organizing centers in epithelial cells? A fly perspective.

  title={Junctions as organizing centers in epithelial cells? A fly perspective.},
  author={Thomas Lecuit and Eric F. Wieschaus},
  volume={3 2},
Junctions isolate the apical from the basal-lateral surfaces and are required for the polarization of epithelial cells. Genetics of junction formation in Drosophila has identified numerous transmembrane and scaffolding proteins that assemble in membrane-associated complexes. This review focuses on recent findings suggesting that junctions are autonomous organizing centers for the establishment and maintenance of apical-basal polarity in epithelial cells as well as other polarized processes such… CONTINUE READING
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