Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination.

@article{Sai2014JunctionallyRR,
  title={Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination.},
  author={Xiaorei Sai and Shigenobu Yonemura and Raj K Ladher},
  journal={Developmental biology},
  year={2014},
  volume={394 2},
  pages={206-16}
}
After induction, the inner ear is transformed from a superficially located otic placode into an epithelial vesicle embedded in the mesenchyme of the head. Invagination of this epithelium is biphasic: phase 1 involves the expansion of the basal aspect of the otic cells, and phase 2, the constriction of their apices. Apical constriction is important not only for otic invagination, but also the invagination of many other epithelia; however, its molecular basis is still poorly understood. Here we… CONTINUE READING
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