Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

Abstract

Members of the LAP protein family, LET-413 in Caenorhabditis elegans, Scribble in Drosophila melanogaster, and Erbin, Lano, Densin-180 and hScrib in mammals, have conserved structural features. LET-413 and Scribble are junctional proteins involved in establishing and maintaining epithelial cell polarity. scribble also behaves as a neoplastic tumor… (More)
DOI: 10.1038/sj.onc.1208632

Topics

10 Figures and Tables

Slides referencing similar topics