Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.

Abstract

Proper insulin secretion requires the coordinated functioning of the numerous beta cells that form pancreatic islets. This coordination depends on a network of communication mechanisms whereby beta cells interact with extracellular signals and adjacent cells via connexin channels. To assess whether connexin-dependent communication plays a role in vivo, we… (More)

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