Junctional adhesion molecules (JAMs): more molecules with dual functions?

  title={Junctional adhesion molecules (JAMs): more molecules with dual functions?},
  author={Klaus Ebnet and Atsushi Suzuki and Shigeo Ohno and Dietmar Vestweber},
  journal={Journal of cell science},
  volume={117 Pt 1},
Junctional adhesion molecules (JAMs) are members of an immunoglobulin subfamily expressed by leukocytes and platelets as well as by epithelial and endothelial cells, in which they localize to cell-cell contacts and are specifically enriched at tight junctions. The recent identification of extracellular ligands and intracellular binding proteins for JAMs suggests two functions for JAMs. JAMs associate through their extracellular domains with the leukocyte beta2 integrins LFA-1 and Mac-1 as well… CONTINUE READING
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