Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration.

@article{JohnsonLger2002JunctionalAM,
  title={Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration.},
  author={Caroline A Johnson-L{\'e}ger and Michel Aurrand-Lions and Nicola Beltraminelli and Nicolas J Fasel and Beat Albert Imhof},
  journal={Blood},
  year={2002},
  volume={100 7},
  pages={
          2479-86
        }
}
The molecular mechanisms underlying lymphocyte extravasation remain poorly characterized. We have recently identified junctional adhesion molecule-2 (JAM-2), and have shown that antibodies to JAM-2 stain high endothelial venules (HEVs) within lymph nodes and Peyer patches of adult mice. Here we show that mouse lymphocytes migrate in greater numbers across monolayers of endothelioma cells transfected with JAM-2. The significance of these findings to an understanding of both normal and pathologic… CONTINUE READING

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