Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin.

@article{Wei2009JunctinAT,
  title={Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin.},
  author={Lan Wei and Esther M. Gallant and Angela F Dulhunty and Nicole A Beard},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 11},
  pages={2214-24}
}
Normal Ca(2+) signalling in skeletal muscle depends on the membrane associated proteins triadin and junctin and their ability to mediate functional interactions between the Ca(2+) binding protein calsequestrin and the type 1 ryanodine receptor in the lumen of the sarcoplasmic reticulum. This important mechanism conserves intracellular Ca(2+) stores, but is poorly understood. Triadin and junctin share similar structures and are lumped together in models of interactions between skeletal muscle… CONTINUE READING
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