JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters.

@article{Chen2011JunDAJ,
  title={JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters.},
  author={Dong Chen and Scott Reierstad and Feng Fang and Serdar E. Bulun},
  journal={Molecular endocrinology},
  year={2011},
  volume={25 5},
  pages={767-75}
}
Aromatase is the key enzyme in estrogen biosynthesis. Normal breast adipose tissue expresses low levels of aromatase via the distal promoter I.4. Breast adipose tissue surrounding a tumor exhibits excessive aromatase expression controlled by proximal aromatase promoters I.3/II, leading to high local levels of estrogen and breast cancer progression. Prostaglandin E(2) (PGE(2)) secreted by malignant breast epithelial cells activates breast cancer-associated aromatase promoters I.3/II, but… CONTINUE READING
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