JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma

  title={JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma},
  author={Toru Kanno and Tomomi Kamba and Toshinari Yamasaki and Noboru Shibasaki and Ryo Saito and Naohiro Terada and Yoshinobu Toda and Yuji Mikami and Takahiro Inoue and Akihiro Kanematsu and Hiroyuki Nishiyama and Osamu Ogawa and Eijiro Nakamura},
Inactivation of the von Hippel–Lindau (VHL) tumor-suppressor gene causes both hereditary and sporadic clear-cell renal-cell carcinoma (ccRCC). Although the best-characterized function of the VHL protein (pVHL) is regulation of hypoxia-inducible factor-α (HIFα), pVHL also controls the development of pheochromocytoma through HIF-independent pathways by regulating JunB. However, it is largely unknown how these pathways contribute to the development and progression of ccRCC. In the present study… CONTINUE READING


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