JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma

@article{Kanno2012JunBPC,
  title={JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma},
  author={Toru Kanno and Tomomi Kamba and Toshinari Yamasaki and Noboru Shibasaki and Ryo Saito and Naohiro Terada and Yoshinobu Toda and Yuji Mikami and Takahiro Inoue and Akihiro Kanematsu and Hiroyuki Nishiyama and Osamu Ogawa and Eijiro Nakamura},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={3098-3110}
}
Inactivation of the von Hippel–Lindau (VHL) tumor-suppressor gene causes both hereditary and sporadic clear-cell renal-cell carcinoma (ccRCC). Although the best-characterized function of the VHL protein (pVHL) is regulation of hypoxia-inducible factor-α (HIFα), pVHL also controls the development of pheochromocytoma through HIF-independent pathways by regulating JunB. However, it is largely unknown how these pathways contribute to the development and progression of ccRCC. In the present study… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

pVHL: a multipurpose adaptor protein.

Science signaling • 2008
View 5 Excerpts
Highly Influenced

Von Hippel-Lindau syndrome: molecular mechanisms of the disease.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico • 2010
View 2 Excerpts

Similar Papers

Loading similar papers…