JunB is required for endothelial cell morphogenesis by regulating core-binding factor β

  title={JunB is required for endothelial cell morphogenesis by regulating core-binding factor $\beta$},
  author={Alexander H. Licht and Oliver T. Pein and Lore Florin and Bettina Hartenstein and Hendrik Reuter and Bernd Arnold and Peter Lichter and Peter Angel and Marina Schorpp-Kistner},
  journal={The Journal of Cell Biology},
  pages={981 - 991}
The molecular mechanism triggering the organization of endothelial cells (ECs) in multicellular tubules is mechanistically still poorly understood. We demonstrate that cell-autonomous endothelial functions of the AP-1 subunit JunB are required for proper endothelial morphogenesis both in vivo in mouse embryos with endothelial-specific ablation of JunB and in in vitro angiogenesis models. By cDNA microarray analysis, we identified core-binding factor β (CBFβ), which together with the Runx… 

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