JunB inhibits proliferation and transformation in B-lymphoid cells.

  title={JunB inhibits proliferation and transformation in B-lymphoid cells.},
  author={Agnieszka P Szremska and Lukas Kenner and Eva Weisz and Rene Georg Ott and Emmanuelle Passegu{\'e} and Michaela Artwohl and Michael Freissmuth and Renate Stoxreiter and H. -Christian Theussl and Sabina Baumgartner Parzer and Richard Moriggl and Erwin F Wagner and Veronika Sexl},
  volume={102 12},
The activator protein 1 (AP-1) member JunB has recently been implicated in leukemogenesis. Here we surveyed human lymphoma samples for expression of JunB and other AP-1 members (c-Jun, c-Fos, Fra1, JunD). JunB was strongly expressed in T-cell lymphomas, but non-Hodgkin B-cell lymphomas do not or only weakly express JunB. We therefore asked whether JunB acted as a negative regulator of B-cell development, proliferation, and transformation. We used transgenic mice that expressed JunB under the… CONTINUE READING

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