Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis

@inproceedings{Tanigawa2013JunDP,
  title={Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis},
  author={Shunsuke Tanigawa and Chan Hee Lee and C L Steve Lin and Claire Carmen Ku and Hitoki Hitoki Hasegawa and Siyue Qin and Atsuo Kawahara and Yoshimi Korenori and Koji Miyamori and Momoko Noguchi and Lay Hoon Lee and Young C. Lin and Yusuke Nakamura and Chunshun Jin and Noritaka Yamaguchi and Richard Eckner and D-X Hou and Kazunari K. Yokoyama},
  booktitle={Cell Death and Disease},
  year={2013}
}
Oxidative stress and reactive oxygen species (ROS) are associated with diseases such as cancer, cardiovascular complications, inflammation and neurodegeneration. Cellular defense systems must work constantly to control ROS levels and to prevent their accumulation. We report here that the Jun dimerization protein 2 (JDP2) has a critical role as a cofactor for transcription factors nuclear factor-erythroid 2-related factor 2 (Nrf2) and small Maf protein family K (MafK) in the regulation of the… CONTINUE READING

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