Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines.

@article{JacobsHelber2004JunNK,
  title={Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines.},
  author={Sarah M. Jacobs-Helber and Stephen T. Sawyer},
  journal={Blood},
  year={2004},
  volume={104 3},
  pages={696-703}
}
Erythropoietin (EPO) is the hormone necessary for development of erythrocytes from immature erythroid cells. EPO activates Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase (MAPK) family in the EPO-dependent murine erythroid HCD57 cells. Therefore, we tested if JNK activity supported proliferation and/or survival of these cells. Treatment with the JNK inhibitor SP600125 inhibited JNK activity and EPO-dependent proliferation of HCD57 cells and the human EPO-dependent… CONTINUE READING