Jumonji histone demethylases as emerging therapeutic targets.

  title={Jumonji histone demethylases as emerging therapeutic targets.},
  author={Sung Yeon Park and Jong-Wan Park and Y. B. Chun},
  journal={Pharmacological research},
The methylation status of lysine residues in histones determines the transcription of surrounding genes by modulating the chromatin architecture. Jumonji domain-containing histone-lysine demethylases (Jmj-KDMs) remove the methyl moiety from lysine residues in histones by utilizing Fe(2+) and α-ketoglutarate. Since genetic alterations in Jmj-KDMs occur in various human cancers, the roles of Jmj-KDMs in cancer development and progression have been investigated, but still controversial. The KDM7… CONTINUE READING
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