Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells.

  title={Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells.},
  author={Mamoru Uemura and Hirofumi Yamamoto and Ichiro Takemasa and Koshi Mimori and Hideyuki Hemmi and Tsunekazu Mizushima and Masataka Ikeda and Mitsugu Sekimoto and Nariaki Matsuura and Yuichiro Doki and Masaki Mori},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={16 18},
PURPOSE This study aimed to identify novel hypoxia-inducible and prognostic markers in vivo from hypoxic tumor cells. EXPERIMENTAL DESIGN Using carbonic anhydrase 9 and CD34 as a guide for hypoxic tumor cells, laser capture microdissection was used to isolate colorectal cancer (CRC) liver metastases. The samples were analyzed by microarray analysis, in parallel with five CRC cell lines cultured under hypoxic conditions. To evaluate the prognostic impact of the expression of certain genes… CONTINUE READING
34 Citations
38 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 34 extracted citations


Publications referenced by this paper.
Showing 1-10 of 38 references

Epithelial - mesenchymal nsition with expression of SNAI 1induced chemoresistance in lorectal cancer

  • H shino, N Miyoshi, K Nagai
  • Biochem Biophys Res Commun
  • 2009

Hypoxia upregulates the tone demethylase JMJD 1 A via HIF - 1

  • G lmlinger, F Yuan, M Dellian, RK Jain
  • Biochem Biophys Res mmun
  • 2008

Overexpression of the gen sensors PHD1 , PHD2 , PHD3 , and FIH is associated with or aggressiveness in pancreatic endocrine tumors

  • A uvelard, L Deschamps, V Rebours
  • Clin Cancer
  • 2008

JHDM 2 A , a JmjCntaining H 3 K 9 demethylase , facilitates transcription activation androgen receptor

  • K mane, C Toumazou, Y Tsukada
  • Nature
  • 2007

Jmjd 1 a and Jmjd 2 c tone H 3 Lys 9 demethylases regulate self - renewal in embryonic m cells

  • W Zhang, X Chen, J George, HH Ng
  • Genes Dev
  • 2007

Antisense to cyclin D 1 inhis vascular endothelial growth factorstimulated growth of vascular othelial cells : implication of tumor vascularization

  • M sui, H Yamamoto, CY Ngan
  • Clin Cancer
  • 2006

Similar Papers

Loading similar papers…