Jugular vein catheterization for repeated blood sampling in the unrestrained conscious rat.

@article{Thrivikraman2002JugularVC,
  title={Jugular vein catheterization for repeated blood sampling in the unrestrained conscious rat.},
  author={K. V. Thrivikraman and Rebecca L. Huot and Paul M. Plotsky},
  journal={Brain research. Brain research protocols},
  year={2002},
  volume={10 2},
  pages={84-94}
}
The ability to obtain repeated, low-stress blood samples from adult rats enables the design of complex experiments in which time course information or evaluation of repeated treatments is necessary. Furthermore, it reduces the number of animals necessary to acquire such information and, thus, facilitates compliance with the animal use 3Rs (reduction, refinement and replacement). To this end, a microsurgical technique to collect blood samples from the right atrium through a catheter (cannula… CONTINUE READING
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