Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription.

@article{Chao2001JugloneAI,
  title={Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription.},
  author={S H Chao and Arno L. Greenleaf and David H Price},
  journal={Nucleic acids research},
  year={2001},
  volume={29 3},
  pages={767-73}
}
The C-terminal domain (CTD) of the large subunit of RNA polymerase II plays a role in transcription and RNA processing. Yeast ESS1, a peptidyl-prolyl cis/trans isomerase, is involved in RNA processing and can associate with the CTD. Using several types of assays we could not find any evidence of an effect of Pin1, the human homolog of ESS1, on transcription by RNA polymerase II in vitro or on the expression of a reporter gene in vivo. However, an inhibitor of Pin1, 5-hydroxy-1,4-naphthoquinone… CONTINUE READING