JournalOfBasicAndApplied-------------------------------------------------------------------------------------------------------- -
@inproceedings{Adachia2017JournalOfBasicAndApplied, title={JournalOfBasicAndApplied-------------------------------------------------------------------------------------------------------- -}, author={Naoya Adachia and Yukie Yoshiib and Takako Furukawac and Mitsuyoshi Yoshimotod and Yasuto Takeuchi and Masayuki Inubushif and Hidekatsu Wakizakag and Ming-Rong and Zhangh and Atsushi B Tsujii and Masashi Takahashij and Yasuhisa Fujibayashik and Tsuneo Sagal}, year={2017} }
Kashiwa, Japan Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7 Kita-Ku, 060-0815, Sapporo, Japan Department of Nuclear Medicine, Kawasaki Medical School,577 Matsushima, 701-0192, Kurashiki, Japan Email: naoya@fml.nirs.go.jp Email: yukiey@nirs.go.jp Email: tfuru@nirs.go.jp Email: miyoshim@ncc.go.jp Email: miyoshim@ncc.go.jp Email: inubushi@med.kawasaki-m.ac.jp Email: wakisaka@nirs.go.jp Email: zhang@nirs.go.jp Email: a_tsuji@nirs.go.jp Email: takahasi@chem.sci.toho-u.ac.jp…
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Investigation of the intratumoral distribution and cellular uptake of 1-(5-fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole (FAZA) and Cu-ATSM shows that although hypoxia affects the buildup of both tracers, the accumulation of Cu- ATSM occurred at milder hypoxial conditions compared to the conditions required for the accumulations of FAZA.
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The intratumoral distribution patterns of 62Cu-ATSM and 18F-FDG were different between SCC and adenocarcinoma in lung cancers, indicating that intrumoral regions of high glucose metabolism and hypoxia could differ with the pathohistologic type of lung cancer.
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It is demonstrated that 62 Cu-ATSM uptake is relatively high in grade IV gliomas and correlates with the MR imaging findings of necrosis, and the 62Cu-AT SM T/B ratio showed significant correlation with HIF-1α expression.
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It is confirmed that Cu-ATSM uptake in tissues in vivo is dependent on the tissue pO2, and that significantly greater uptake and retention occur in hypoxic tumor tissue.
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Cu-ATSM exhibits selectivity for hypoxic tumor tissue both in vivo and in vitro and may provide a successful diagnostic modality for the detection of tumor ischemia.