Corpus ID: 207857122

Joseph near the Mitochondrial DNA Nucleoid Positioned to Modify Nascent rRNA in Foci Methyltransferase Family Members Are Mitochondrial Ribosomal RNA ( rRNA )

  title={Joseph near the Mitochondrial DNA Nucleoid Positioned to Modify Nascent rRNA in Foci Methyltransferase Family Members Are Mitochondrial Ribosomal RNA ( rRNA )},
  author={Ken-Wing Lee and C. Okot-Kotber and Joseph F. Lacomb and D. Bogenhagen},


A bright and photostable photoconvertible fluorescent protein for fusion tags
An EosFP variant that functions well in a broad range of protein fusions for dynamic investigations, exhibits high photostability and preserves the ∼10-nm localization precision of its parent is reported. Expand
Functional requirement of a site-specific ribose methylation in ribosomal RNA.
The purified Pet56 protein catalyzed the site-specific formation of 2'-O-methylguanosine on in vitro transcripts of both mitochondrial 21S rRNA and Escherichia coli 23S r RNA, providing evidence for an essential modified nucleotide in rRNA. Expand
rRNA modifications and ribosome function.
Three-dimensional maps of the modified nucleotides in the ribosomes of Escherichia coli and yeast suggest that many ribosome functions benefit from nucleotide modification. Expand
The Layered Structure of Human Mitochondrial DNA Nucleoids*
It is shown that an N-terminal domain of ATAD3 previously proposed to bind to the mtDNA D-loop is directed away from the mitochondrial matrix, so it is unlikely to interact with mtDNA in vivo. Expand
GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules
Summary Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequenceExpand
Human mitochondrial RNA decay mediated by PNPase–hSuv3 complex takes place in distinct foci
It is demonstrated that silencing of human polynucleotide phosphorylase (PNPase) causes accumulation of RNA decay intermediates and increases the half-life of mitochondrial transcripts, providing indirect evidence that degradosome-dependent mitochondrial RNA decay takes place in foci. Expand
Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome
Four previously known proteins are established as MRPs and the identification of ICT1 (MRP58) as a ribosomal protein is confirmed and the essential roles of CHCHD1, AURKAIP1, and CRIF1 are demonstrated by siRNA knock-down studies. Expand
MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals
It is demonstrated here that decreased expression of MTERF3 not only leads to activation of mtDNA transcription, but also impairs assembly of the large mitochondrial ribosomal subunit. Expand
Par RNA Methyltransferase Family Members at mtDNA Nucleoids 31398 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME
  • 2013
The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.
It is shown that GRSF1, previously implicated in the binding and selective translation of influenza mRNAs, is targeted to mitochondria where it forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids. Expand