Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.

@article{Storm1996JointPD,
  title={Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.},
  author={Elaine E. Storm and David M. Kingsley},
  journal={Development},
  year={1996},
  volume={122 12},
  pages={3969-79}
}
The mouse brachypodism locus encodes a bone morphogenetic protein (BMP)-like molecule called growth/differentiation factor 5 (GDF5). Here we show that Gdf5 transcripts are expressed in a striking pattern of transverse stripes within many skeletal precursors in the developing limb. The number, location and time of appearance of these stripes corresponds to the sites where joints will later form between skeletal elements. Null mutations in Gdf5 disrupt the formation of more than 30% of the… CONTINUE READING
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