Joint pathology and platelet-rich plasma therapies

@article{Andia2012JointPA,
  title={Joint pathology and platelet-rich plasma therapies},
  author={Isabel Andia and Mik{\`e}l Sanchez and Nicola Maffulli},
  journal={Expert Opinion on Biological Therapy},
  year={2012},
  volume={12},
  pages={22 - 7}
}
Introduction: At the beginning of the new millennium, there was a breakthrough in platelet-rich plasma (PRP) therapy for tissue repair. The mechanisms governing the effects of this therapy in joint pathology remain largely unexplored. Areas covered: This review is primarily based on PubMed and Web of Knowledge searches with the terms osteoarthritis in combination with PRP, treatment, cartilage, synovium, platelets, inflammation and/or angiogenesis. This search was completed by a manual search… 
Platelet-rich plasma for managing pain and inflammation in osteoarthritis
TLDR
Understanding PRP in molecular terms could help to exploit its therapeutic potential, and aid the development of novel treatments and tissue-engineering approaches, for the different stages of joint degeneration.
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TLDR
Combining PRP and HA may benefit from their dissimilar biological mechanisms and help in controlling delivery and presentation of signaling molecules, as well as modify deleterious fluidic microenvironments.
Nature Reviews UNCORRECTED PROOF
TLDR
Understanding PRP in molecular terms could help to exploit its therapeutic potential, and aid the development of novel treatments and tissue-engineering approaches, for the different stages of joint degeneration.
Does platelet-rich plasma have a role in the treatment of osteoarthritis?
Anti-inflammatory and Matrix Restorative Mechanisms of Platelet-Rich Plasma in Osteoarthritis: Response to Andia and Maffulli
TLDR
Although PRP plays an important role in osteoarthritic inflammation, as recently reviewed, PRP is not unequivocally anti-inflammatory, and at least 3 plasma proteins activate macrophages via the innate immune toll-like receptor (TLR) TLR4 and induce the expression of TNF-a,IL-1b, IL-6, and vascular endothelial growth factor (VEGF).
Biology of platelet-rich plasma and its clinical application in cartilage repair
TLDR
Clinical trials suggest that PRP may have the potential to fill cartilage defects to enhance cartilage repair, attenuate symptoms of osteoarthritis and improve joint function, with an acceptable safety profile.
Considerations for the Use of Platelet-Rich Plasma in Orthopedics
TLDR
Platelet-rich plasma appears to be a safe treatment option with a variety of potentially beneficial effects to injured musculoskeletal tissues, and its future understanding will dictate ‘customizing’ the PRP preparation to the specific pathology of interest.
Platelet-rich plasma: underlying biology and clinical correlates.
TLDR
Clinical data suggest that PRPs may exploit different regenerative mechanisms under diverse disease conditions, including hemostasis, inflammation, angiogenesis and the synthesis of extracellular matrix.
Role of Platelets in Osteoarthritis—Updated Systematic Review and Meta-Analysis on the Role of Platelet-Rich Plasma in Osteoarthritis
TLDR
Multiple randomized controlled trials included in the systematic review and meta-analyses prove the effectiveness of platelet-rich plasma (PRP) as a minimally invasive method of pain alleviation in osteoarthritis treatment.
Platelet Rich Plasma in Articular Cartilage Lesions
TLDR
A critical review of the available literature was performed with regards to PRP use in surgical and conservative treatment of cartilage lesions or osteoarthritis in the main weight-bearing joints: knee, hip and ankle.
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