Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study.

@article{Peila2001JointEO,
  title={Joint effect of the APOE gene and midlife systolic blood pressure on late-life cognitive impairment: the Honolulu-Asia aging study.},
  author={Rita L Peila and Lon R. White and Helen Petrovich and Katsunori Masaki and George Webster Ross and Richard J. Havlik and Lenore J. Launer},
  journal={Stroke},
  year={2001},
  volume={32 12},
  pages={2882-9}
}
BACKGROUND AND PURPOSE The aim of this study was to explore the joint effect of the APOE epsilon4 allele and midlife systolic blood pressure (SBP) on the risk for poor cognitive function in late life. METHODS The study includes 3605 surviving members of the cohort of the Japanese-American men followed prospectively over 26 years (1965-1991) as a part of the Honolulu Heart Program. In 1965 men were aged 45 to 68 years and were living in the island of Oahu, Hawaii. For this study the sample was… CONTINUE READING

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