Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms

@inproceedings{YDCOLQUHOU2001JointDO,
  title={Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms},
  author={N YDCOLQUHOU and N AGHAWKESA and I DKSRODZINSK},
  year={2001}
}
  • Y D C O L Q U H O U N, A G H A W K E S ~ A N, D K S R O D Z I N S K I
  • Published 2001
The openings and shuttings of intlivithlal ion channel molecules can be motlelletl in terms of an underlying Markov process with discrete states in contimlous time. In practice, some of the open times, and/or shut times, are too short to be detected reliably, making the thlrations of some of these intervals appear to he longer than they really are. Under certain assumptions about how this happens, the probability densities of these apparent times have previously been obtained. It has h e n… CONTINUE READING

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