Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms

@article{Colquhoun1996JointDO,
  title={Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms},
  author={David Colquhoun and Alan G. Hawkes and K. Srodzinski},
  journal={Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences},
  year={1996},
  volume={354},
  pages={2555 - 2590}
}
  • D. Colquhoun, A. Hawkes, K. Srodzinski
  • Published 1 November 1996
  • Mathematics
  • Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences
The openings and shuttings of individual ion channel molecules can be modelled in terms of an underlying Markov process with discrete states in continuous time. In practice, some of the open times, and/or shut times, are too short to be detected reliably, making the durations of some of these intervals appear to be longer than they really are. Under certain assumptions about how this happens, the probability densities of these apparent times have previously been obtained. It has been shown that… 
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