Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility

  title={Joint Effect of Multiple Common SNPs Predicts Melanoma Susceptibility },
  author={Shenying Fang and Jiali Han and MingFeng Zhang and Lei Wang and Qingyi Wei and Christopher I. Amos and Jeffrey E. Lee},
  booktitle={PloS one},
Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and Harvard Medical School investigations. Participants with ≥15 risk alleles were 5… CONTINUE READING
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