Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia

  title={Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer's Disease and Frontotemporal Dementia},
  author={Yu Zhang and Norbert Schuff and Christopher R. K. Ching and Duygu Tosun and Wang Zhan and Marzieh Nezamzadeh and Howard J. Rosen and Joel H. Kramer and Maria Luisa Gorno-Tempini and Bruce L. Miller and Michael W Weiner},
  journal={International Journal of Alzheimer's Disease},
Most MRI studies of Alzheimer's disease (AD) and frontotemporal dementia (FTD) have assessed structural, perfusion and diffusion abnormalities separately while ignoring the relationships across imaging modalities. This paper aimed to assess brain gray (GM) and white matter (WM) abnormalities jointly to elucidate differences in abnormal MRI patterns between the diseases. Twenty AD, 20 FTD patients, and 21 healthy control subjects were imaged using a 4 Tesla MRI. GM loss and GM hypoperfusion were… 
White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration
FTLD and AD have significant WM and GM defects and a combination of DTI and volumetric MRI modalities provides a quantitative method for distinguishing FTLD andAD in vivo.
MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes.
DTI overall provided significantly greater accuracy for FTLD classification than brain atrophy and radial diffusivity was more sensitive in assessing white matter damage in FTLD than other DTI indices.
Neuroimaging in frontotemporal dementia
Three main subtypes of frontotemporal dementia are described, behavioural variant FTD (bvFTD), two sub types of the language presentation (known as primary progressive aphasia or PPA) called semantic variant of PPA and non-fluent variant ofPPA, and newer imaging techniques have the potential to improve the differential diagnosis of FTD from other disorders and to provide more informative imaging signatures ofFTD syndromes.
The power of neuroimaging biomarkers for screening frontotemporal dementia
A data‐driven VOI approach using Eigenanatomy provides more accurate classification, benefits from increased statistical power in unseen datasets, and therefore provides a robust method for screening underlying pathology in FTD patients for entry into clinical trials.
Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease
MRI scans in cognitively healthy subjects with and without microtubule-associated protein Tau (MAPT) or progranulin (GRN) mutations were acquired to investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between Cognitively healthy carriers of pathogenic FTD mutations, and cognitivelyhealthy carriers at increased AD risk.
Can MRI screen for CSF biomarkers in neurodegenerative disease?
MRI may serve as a noninvasive procedure that can screen for AD and FTLD pathology as a surrogate for CSF biomarkers and is 75% accurate at identifying underlying diagnosis in patients with known pathology and in clinically diagnosed patients withknown CSF tt/Aβ levels.
Diffusion Tensor Tractography versus Volumetric Imaging in the Diagnosis of Behavioral Variant Frontotemporal Dementia
The results indicate that DTI could offer advantages in comparison with the assessment of cortical volume in differentiating patients with behavioral variant frontotemporal dementia and controls.
Early-stage differentiation between presenile Alzheimer’s disease and frontotemporal dementia using arterial spin labeling MRI
ASL-MRI contributes to early diagnosis of and differentiation between presenile AD and FTD, and facilitates differentiation of early Alzheimer’s disease and frontotemporal dementia.
How far is arterial spin labeling MRI from a clinical reality? Insights from arterial spin labeling comparative studies in Alzheimer's disease and other neurological disorders
  • Jing Zhang
  • Medicine, Biology
    Journal of magnetic resonance imaging : JMRI
  • 2016
It is necessary to optimize and standardize ASL parameters and explore new techniques to overcome the limitations of ASL and make it a clinical imaging alternative to invasive FDG-PET/SPECT/DSC/ DCE in the diagnosis of AD and other neurological disorders.


White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
The regional patterns of anisotropy reduction in FTD and Alzheimer's disease compared to controls suggest a characteristic distribution of white matter degradation in each disease.
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI
ASL-MRI detected a pattern of hypoperfusion in right frontal regions in patients with FTD vs CN subjects, similar to PET and SPECT, which could contribute to the differential diagnosis between frontotemporal dementia and Alzheimer disease.
Diffusion tensor imaging in early Alzheimer's disease
White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
White matter changes in patients with Alzheimer's disease are likely to be secondary to wallerian degeneration of fibre tracts due to neuronal loss in cortical associative areas.
Patterns of white matter atrophy in frontotemporal lobar degeneration.
Results show that patients with frontotemporal lobar degeneration who are in relatively early stages of the disease have WM atrophy that largely parallels the pattern of GM atrophy typically associated with these disorders.
Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia
The clinical diagnostic value of magnetic resonance imaging and single photon emission computed tomography (SPECT) in the differentiation of one form of dementia from another from amongst a group of AD, FTD and VaD was examined.
Alterations in Cortical Thickness and White Matter Integrity in Mild Cognitive Impairment Measured by Whole-Brain Cortical Thickness Mapping and Diffusion Tensor Imaging
DTI and cortical thickness analyses may both serve as imaging markers to differentiate MCI from normal aging and combined use of these 2 methods may improve the accuracy of MCI diagnosis.
Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia.
The fvFTD and tvFTD variants are associated not only with selective local GM reductions but also with significant WM damage in early disease phase and could be responsible for the further progression of atrophy in the later disease stages.
Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe
Evidence is found for functionally relevant microstructural changes in the NAWM of patients with AD and MCI that were present in brain regions serving higher cortical functions, but not in regions serving primary functions, and are consistent with a hypothesized loss of axonal processes in the temporal lobe.
MRI with Diffusion Tensor Imaging Post-Mortem at 3.0 T in a Patient with Frontotemporal Dementia
Examination of the formalin-fixed brain of a patient with clinically diagnosed frontotemporal dementia using magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) with histopathologic correlation will enhance the understanding of the basis of white matter changes observed in dementia patients and may improve the in vivo MRI/DTI diagnostic assessment in FTD.