John Maynard Smith. 6 January 1920 – 19 April 2004

  title={John Maynard Smith. 6 January 1920 – 19 April 2004},
  author={Brian Charlesworth and P. H. Harvey},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  pages={253 - 265}
  • B. Charlesworth, P. Harvey
  • Published 1 December 2005
  • Biology, Chemistry
  • Biographical Memoirs of Fellows of the Royal Society
Gordon Lowe made major contributions to the understanding of the mechanisms of enzyme action, pioneering the use in particular of novel isotopically chiral phosphate and sulphate esters. In the latter part of his scientific work he discovered new peptide nucleic acids, probed the interaction of platinum complexes with enzymes, leading to potential new antimalarial drugs, and discovered, by combinatorial methods, effective active-site enzyme inhibitors. 
4 Citations
A Reflection on 50 Years of John Maynard Smith’s “Protein Space”
It is proposed that the Protein Space analogy is not only important because of its scientific richness, but also because of what it can teach us about the art of constructing useful and subversive analogies.
Complicating the Story of Popular Science: John Maynard Smith’s “Little Penguin” on The Theory of Evolution
  • Helen Piel
  • Education
    Journal of the history of biology
  • 2019
This work provides a microhistory of the early popular writings of evolutionary biologist John Maynard Smith by linking them to the state of evolutionary biology as a professional science as well as MaynardSmith’s own professional standing and examines the interplay between author, text and audiences.
Game theory and evolution (1973)
In 1973 Maynard Smith and Price published an article analyzing why animals avoided using their most dangerous weapons in intraspecific conflicts, one of those that launched the application of game theory to evolutionary problems.
John Maynard Smith
  • C. Watkins
  • Philosophy
    Encyclopedia of Evolutionary Psychological Science
  • 2019


Almost 20% of the patients with quiescent disease at 1 year have a bacteriological relapse after stopping chemotherapy, so that the overall efficacy of the 2-drug regimens is reduced to less than 70% even among those patients who consume the drugs regularly.
Developmental Constraints and Evolutionary Saltations: A Discussion and Critique
This essay discusses the concepts of constraint and saltation critically in the context of development; many might be governed by developmental constraints which do not permit continuity of form in polymorphic populations.
An empirical test of the mutational landscape model of adaptation using a single-stranded DNA virus
The first empirical examination of Gillespie's model for adaptive evolution is provided, using a single-stranded DNA bacteriophage related to φX174, and it is found that the data are consistent with Orr's predictions, provided that the model is adjusted to incorporate mutation bias.
How clonal are bacteria?
Data from multilocus enzyme electrophoresis of bacterial populations were analyzed using a statistical test designed to detect associations between genes at different loci, and found panmictic, epidemic, and clonal population structures.
The hitch-hiking effect of a favourable gene.
If the selective coefficients at the linked locus are small compared to those at the substituted locus, it is shown that the probability of complete fixation at thelinked locus is approximately exp (— Nc), where c is the recombinant fraction and N the population size.
How clonal are human mitochondria?
It seems likely that recombination has occurred between mitochondrial lineages in humans, given the large number of homoplasies found in phylogenetically informative trees constructed using human mitochondrial sequences.
Detecting recent positive selection in the human genome from haplotype structure
A framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations is introduced, and the core haplotypes carrying the proposed protective mutation stand out and show significant evidence of selection.
The distribution of fitness effects among beneficial mutations.
Using extreme value theory, this distribution of fitness effects among new beneficial mutations is derived and it is shown that it has two unexpected properties: first, the distribution of beneficial fitness effects at a gene is exponential, and second, it has the same mean regardless of the fitness of the present wild-type allele.
The genetical evolution of social behaviour. II.
The genetical evolution of social behaviour. I.