Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation.

@article{Jung2015Jmjd2CIM,
  title={Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation.},
  author={Eun-Shil Jung and Ye-Ji Sim and Hoe-Su Jeong and Su-Jin Kim and Ye-Jin Yun and Joo-Hoon Song and Su-Hee Jeon and Chung-youl Choe and Kyung-Tae Park and Chang-Hoon Kim and Kye-Seong Kim},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1849 8},
  pages={1081-94}
}
Skeletal muscle cell differentiation requires a family of proteins called myogenic regulatory factors (MRFs) to which MyoD belongs. The activity of MyoD is under epigenetic regulation, however, the molecular mechanism by which histone KMTs and KDMs regulate MyoD transcriptional activity through methylation remains to be determined. Here we provide evidence for a unique regulatory mechanism of MyoD transcriptional activity through demethylation by Jmjd2C demethylase whose level increases during… CONTINUE READING
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