Jet fuel-induced immunotoxicity

@article{Harris2000JetFI,
  title={Jet fuel-induced immunotoxicity},
  author={David T. Harris and Debbie Sakiestewa and Dominic Titone and Raymond F Robledo and R. S. Young and Mark L. Witten},
  journal={Toxicology and Industrial Health},
  year={2000},
  volume={16},
  pages={261 - 265}
}
Chronic exposure to jet fuel has been shown to cause human liver dysfunction, emotional dysfunction, abnormal electroencephalograms, shortened attention spans, and to decrease sensorimotor speed (3-5). Exposure to potential environmental toxicants such as jet fuel may have significant effects on host systems beyond those readily visible (e.g., physiology, cardiology, respiratory, etc.), e.g., the immune system. Significant changes in immune function, even if short-lived, may have serious… 
The influence of hydrocarbon composition and exposure conditions on jet fuel-induced immunotoxicity
TLDR
Real-time, in-line monitoring of jet fuel exposure resulted in aerosol exposure concentrations that were approximately one-eighth the concentration of previously reported exposure systems, and the effects of a synthetic jet fuel designed to eliminate polycyclic aromatic hydrocarbons were examined.
Immunotoxicity Evaluation of Jet A Jet Fuel in Female Rats After 28-Day Dermal Exposure
TLDR
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TLDR
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Effects of in utero JP-8 jet fuel exposure on the immune systems of pregnant and newborn mice
TLDR
Overall, the data showed that in-utero JP-8 jet fuel exposure had long-term detrimental effects on newborn mice, particularly on the viability and immune competence of male offspring.
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TLDR
There was a decrease in alpha1-anti-trypsin expression suggesting that JP-8 jet fuel exposure may have implications for the development of pulmonary disorders.
Systemic molecular and cellular changes induced in rats upon inhalation of JP-8 petroleum fuel vapor
TLDR
Tissue changes were observed histologically (hematoxylin and eosin staining) in liver, kidney, lung, bone marrow, and heart, and more prevalently at medium or high JP-8 vapor phase exposures than at low vapor phase exposure (250 mg/m3) or non-JP-8 controls.
Epigenome-wide association study for transgenerational disease sperm epimutation biomarkers following ancestral exposure to jet fuel hydrocarbons.
TLDR
Observations show disease specific differential DNA methylation regions (DMRs) called epimutations in the transgenerational F3 generation great-grand-offspring male rats ancestrally exposed to jet fuel have the potential to transgenerationally transmit disease susceptibilities to subsequent generations.
JP-8 jet fuel can promote auditory impairment resulting from subsequent noise exposure in rats.
TLDR
JP-8 exposure did result in a significant depletion of total GSH that was observable in liver with a nonsignificant trend toward depletion in the brain and lung raising the possibility that the promotion of noise-induced hearing loss by JP-8 might have resulted from oxidative stress.
Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations.
TLDR
Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures, and analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutation.
A review of health effects associated with exposure to jet engine emissions in and around airports
TLDR
Though the literature is scarce and with low consistency in methods and measured biomarkers, there is evidence that jet engine emissions have physicochemical properties similar to diesel exhaust particles, and that exposure toJet engine emissions is associated with similar adverse health effects as exposure to dieselhaust particles and other traffic emissions.
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References

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TLDR
It appears that the immune system may be the most sensitive indicator of toxicological damage due to JP-8 exposure, as effects were seen at concentrations of jet fuel that did not evidence change in other biological systems, which may have significant effects on the health of the exposed individual.
Short-Term Exposure To Jp-8 Jet Fuel Results in Longterm Immunotoxicity
TLDR
It appears that the immune system may be the most sensitive indicator of toxicological damage due to JP-8 exposure, as it was observed that decreases in viable immune cell numbers and immune organ weights found at 24 h after exposure persisted for extended periods of time.
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TLDR
It is indicated that jet fuel, which is a mixture of aliphatic and aromatic organic solvents resembling gasoline and white spirit, is an inducer of hepatic drug metabolism in man.
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TLDR
Recovery from the early pulmonary effects of JP‐8 inhalation occurred with continued exposure, as seen by recovery of pulmonary compliance and WtL/WtB.
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TLDR
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TLDR
The male rat kidney developed a reversible ultrastructural increase in size and propensity for crystalloid changes of phagolysosomal proteinic reabsorption droplets in the proximal convoluted tubular epithelium, comparable to the chronic effect of lifetime exposure of the male rat to unleaded gasoline, d-limonene, and p-dichlorobenzene, except for the absence of tubular tumorigenesis.
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TLDR
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TLDR
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TLDR
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TLDR
Aviation turbine fuels (jet fuels) are similar to other petroleum products that have a boiling range of approximately 300F to 550F and the freezing point and flash point are the principle differences between the finished fuels.
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