Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers

Abstract

The secreted protein Jelly belly (Jeb) is required for an essential signalling event in Drosophila muscle development. In the absence of functional Jeb, visceral muscle precursors are normally specified but fail to migrate and differentiate. The structure and distribution of Jeb protein implies that Jeb functions as a signal to organize the development of… (More)
DOI: 10.1038/nature01916

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