Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers

@article{Lee2003JellyBP,
  title={Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers},
  author={Hsiu-Hsiang Lee and Audra Norris and Joseph B. Weiss and Manfred Frasch},
  journal={Nature},
  year={2003},
  volume={425},
  pages={507-512}
}
The secreted protein Jelly belly (Jeb) is required for an essential signalling event in Drosophila muscle development. In the absence of functional Jeb, visceral muscle precursors are normally specified but fail to migrate and differentiate. The structure and distribution of Jeb protein implies that Jeb functions as a signal to organize the development of visceral muscles. Here we show that the Jeb receptor is the Drosophila homologue of anaplastic lymphoma kinase (Alk), a receptor tyrosine… 
The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.
TLDR
The results suggest that either mouse ALK and "mouse Jeb" have co-evolved to the extent that mALK can no longer recognise the Drosophila Jeb ligand or that the mALK RTK has evolved such that it is no longer activated by a Jeb-like molecule in vertebrates.
Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm
TLDR
The results suggest that Lmd is a target of Jeb/Alk signalling in the VM of Drosophila embryos, and the ability of Alk signalling to downregulate Lmd protein requires the N-terminal 140 amino acids.
Jelly belly trans‐synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture
TLDR
Novel roles for Jeb–Alk signaling in the modulation of synaptic function and structure have potential implications for recently reported Alk functions in human addiction, retention of spatial memory, cognitive dysfunction in neurofibromatosis, and pathogenesis of amyotrophic lateral sclerosis.
The scaffolding protein Cnk Interacts with Alk to Promote Visceral Founder Cell Specification in Drosophila
TLDR
It is reported that the scaffolding protein Cnk interacts directly with Alk via a novel c-terminal binding motif and represents the first molecules downstream of Alk whose loss genocopies the lack of visceral FC-specification of AlK and jeb mutants indicating an essential role in Alk-signalling.
The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila
TLDR
A critical role is identified for the scaffolding protein Cnk (connector enhancer of kinase suppressor of Ras) in this signaling pathway, which facilitates activation of the receptor tyrosine kinase ALK pathway in the visceral mesoderm of Drosophila larvae.
The Receptor Tyrosine Kinase Alk Controls Neurofibromin Functions in Drosophila Growth and Learning
TLDR
dAlk is identified as an upstream activator of dNf1-regulated Ras signaling responsible for several dNF1 defects, and human Alk is implicate as a potential therapeutic target in NF1.
Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap
TLDR
It is concluded that Jeb-Alk expression and anterograde trans-synaptic signaling are modulated by Mtg and play a key role in establishing functional synaptic connectivity in the developing motor circuit.
The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.
DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as Alk target in the Drosophila visceral mesoderm
TLDR
A rich dataset of Alk responsive loci in the embryonic VM is reported, the first functional characterization of the Kah transcription factor is provided, and a model in which Kah and Pnt cooperate in embryonic midgut morphogenesis is suggested.
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References

SHOWING 1-10 OF 31 REFERENCES
The gene tinman is required for specification of the heart and visceral muscles in Drosophila.
TLDR
It is shown that the function of tinman is required for visceral muscle and heart development, and tinman seems to be one of the earliest genes required for heart development and the first gene reported for which a crucial function in the early mesodermal subdivisions has been implicated.
MAP kinase in situ activation atlas during Drosophila embryogenesis.
TLDR
The capacity to follow the active state of these signaling pathways in situ is described by monitoring, with a specific monoclonal antibody, the distribution of the active, dual phosphorylated form of MAP kinase (ERK).
Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm.
TLDR
It is concluded that distinct cellular identity codes are generated by the combinatorial activities of Wg, Dpp, EGF, and FGF signals in the progressive determination of embryonic mesodermal cells.
Identification of Anaplastic Lymphoma Kinase as a Receptor for the Growth Factor Pleiotrophin*
TLDR
It is proposed that the PTN-ALK axis can play a significant role during development and during disease processes because of the growth stimulatory effect of PTN on different cell lines in culture coincides with the endogenous expression of ALK mRNA.
Myoblast fusion in Drosophila.
  • H. Dworak, H. Sink
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2002
TLDR
The cellular studies, and the recent genetic and biochemical analyses that uncovered interacting extracellular molecules present on fusing myoblasts and the intracellular effectors that facilitate fusion in Drosophila are reviewed.
Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
TLDR
It is shown that an inductive signal from dorsal ectodermal cells is required for activation of tinman in the underlying mesoderm and present evidence that Decapenta-plegic (Dpp), a member of the transforming growth factor-β superfamily, serves as a signalling molecule in this process.
biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila.
TLDR
It is proposed that the splanchnic mesoderm layers in Drosophila and vertebrate embryos are homologous structures whose development into gut musculature and other visceral organs is critically dependent on FoxF genes.
The embryonic development of larval muscles in Drosophila.
TLDR
Evidence is presented for the view that the development of the larval muscle pattern in Drosophila depends on a prior segregation of founder cells at appropriate locations in the mesoderm with which other cells fuse to form the precursors.
tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.
TLDR
Two homeo box genes are described, tinman (tin) and bagpipe (bap), which spatially subdivide the mesoderm and determine cell fates in the dorsal Mesoderm, and these two genes are components of a cascade of genetic interactions that result in the spatial restriction of tin mRNA to the dorsal mesderm and in the activation of bap in segmental clusters of cells in this region.
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