Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?

@inproceedings{Vaillant2011JekyllOH,
  title={Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?},
  author={François Vaillant and Geoffrey J Lindeman and Jane E. Visvader},
  booktitle={Breast Cancer Research},
  year={2011}
}
In vivo transplantation is the current 'gold-standard' assay for evaluating mammary stem cell (MaSC) function. Matrigel, a reconstituted extracellular matrix derived from a mouse sarcoma line, is increasingly being utilized for mammary repopulating assays, although original studies were carried out in its absence. This matrix has also been shown to enhance tumor-initiating capacity. Whilst Matrigel increases the rate of engraftment by MaSCs, it also appears to promote progenitor activity that… CONTINUE READING

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