The yin and yang of neurotrophin action
- BiologyNature Reviews Neuroscience
The proteolytic cleavage of proneurotrophins represents a mechanism that controls the direction of action of neurotrophins and has profound implications for the understanding of the role of neurotrophic molecules in a wide range of cellular processes.
Differential regulation of macrophage phenotype by mature and pro-nerve growth factor
- BiologyJournal of Neuroimmunology
Understanding proneurotrophin actions: Recent advances and challenges
- BiologyDevelopmental neurobiology
Emerging evidence for a novel transmembrane mechanism for ligand‐specific p75NTR activation and several mechanisms by which p 75NTR‐dependent apoptotic and nonapoptotic responses can be selective activated are reviewed.
Oligodendroglial Cells and Neurotrophins: A Polyphonic Cantata in Major and Minor
- BiologyJournal of Molecular Neuroscience
Experimental evidence of studies are presented which support the idea that neurotrophins are promising candidates for improving oligodendroglial regeneration and remyelination.
Vertebrate thymus and the neurotrophin system.
- Biology, MedicineInternational review of cytology
ProNGF, Sortilin, and Age‐related Neurodegeneration
- BiologyAnnals of the New York Academy of Sciences
Preliminary data now indicate that proNGF is indeed neurotoxic for aged, but not young, NGF‐responsive basal forebrain and sympathetic neurons and that blockade of sortilin rescuesProNGF‐induced cell death and is proposed to contribute to age‐related neuronal atrophy and degeneration.
Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR*
- BiologyJournal of Biological Chemistry
Following assembly and purification of soluble p75NTR·NGF complexes, mass spectrometry, analytical ultracentrifugation, and solution x-ray scattering measurements are indicative of 2:2 stoichiometry, which implies a symmetric complex.
p75NTR Antagonistic Cyclic Peptide Decreases the Size of β Amyloid-Induced Brain Inflammation
- Biology, ChemistryCellular and Molecular Neurobiology
A p75NTR antagonistic peptide (CATDIKGAEC) is synthesized that contains the KGA motif that is present in the toxic part of Aβ and closely resembles the binding site of NGF for p 75NTR to reduce neuronal loss in Alzheimer’s disease.
SHOWING 1-10 OF 38 REFERENCES
Regulation of Cell Survival by Secreted Proneurotrophins
It is shown that the proforms of nerve growth factor (NGF) and the pro forms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix metalloproteinases (MMPs).
Neurotrophin signaling via Trks and p75.
- BiologyExperimental cell research
This review focuses on recent advances in the understanding of receptor-mediated signaling by the neurotrophins NGF, BDNF, NT3, and NT4/5, and p75, a universal receptor for neurotrophin that is a member of the TNF receptor/Fas/CD40 superfamily.
Induction of cell death by endogenous nerve growth factor through its p75 receptor
The results indicate that, as with cells of the immune system, the death of neurons in the central nervous system can also be induced by ligands, and that the effect of NGF on cell fate depends on the type of receptor expressed by developing neurons.
Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75
- Biology, ChemistryScience
In the absence of TrkA, NGF binding to p75NTR activated the transcription factor nuclear factor kappa B (NF-κB) in rat Schwann cells, and the effect was selective for NGF; NF-κBs was not activated by BDNF or NT-3.
Neurotrophin Binding to the p75 Receptor Modulates Rho Activity and Axonal Outgrowth
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
Results indicate that NGF has the ability to promote cell death in specific cell types through a ligand-dependent signalling mechanism involving the p75 neurotrophin receptor.
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
- BiologyThe EMBO journal
A close proximity of the two neurotrophin receptors within cell membranes is indicated, and it is suggested that the signalling pathways they initiate may interact soon after their activation.
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
- BiologyThe Journal of Neuroscience
Results indicate that TrkA-mediated rescue involves not only activation of survival signals but also simultaneous suppression of a death signal by p75, a novel mechanism that achieves alternative cellular responses by merging signals from different ligand–receptor systems.