Gastric and colon interposition are the commonly used in esophageal operations. In this report, Two jejunal esophageal interposition cases are presented. In the first patient, a free jejunal interposition graft was used to re-establish swallowing route in a patient who suffered severe esophageal and gastric chemical burn, and failure of colon interposition graft. The second patient had a leak of Roux-en-Y jejuno-esophageal anastomosis performed after resection of gastric adenocarcinoma. The patient developed subdiaphragmatic abscesses and empyema. The esophageal-intestinal continuity was re-established with a new Roux-en-Y jejuno-esophageal anastomosis through a right thoracotomy. Jejunal graft should be considered in salvage esophageal substitution.