Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion

@article{Englund2003JebST,
  title={Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion},
  author={Camilla Englund and Christina E. Lor{\'e}n and Caroline Grabbe and Gaurav K. Varshney and Fabienne Deleuil and Bengt Hallberg and Ruth H. Palmer},
  journal={Nature},
  year={2003},
  volume={425},
  pages={512-516}
}
The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). We have previously shown that the Drosophila Alk RTK is crucial for visceral mesoderm development during early embryogenesis. Notably, observed Alk visceral mesoderm defects are highly reminiscent of the phenotype reported for the secreted molecule Jelly belly (Jeb). Here we show that Drosophila Alk is the receptor for Jeb in the… 
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TLDR
The results suggest that Lmd is a target of Jeb/Alk signalling in the VM of Drosophila embryos, and the ability of Alk signalling to downregulate Lmd protein requires the N-terminal 140 amino acids.
The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
dAlk is identified as an upstream activator of dNf1-regulated Ras signaling responsible for several dNF1 defects, and human Alk is implicate as a potential therapeutic target in NF1.
Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut.
TLDR
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DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as Alk target in the Drosophila visceral mesoderm
TLDR
A rich dataset of Alk responsive loci in the embryonic VM is reported, the first functional characterization of the Kah transcription factor is provided, and a model in which Kah and Pnt cooperate in embryonic midgut morphogenesis is suggested.
Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells
TLDR
It is shown that Alk expression leads to a growth advantage and induces cell death in surrounding cells, which can be reversed by over-expression of the JNK kinase kinase Wnd.
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