Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?

@article{Beverdam2002JawTW,
  title={Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?},
  author={Annemiek Beverdam and G. Merlo and L. Paleari and S. Mantero and F. Genova and O. Barbieri and P. Janvier and G. Levi},
  journal={genesis},
  year={2002},
  volume={34}
}
Summary: In modern vertebrates upper and lower jaws are morphologically different. Both develop from the mandibular arch, which is colonized mostly by Hox‐free neural crest cells. Here we show that simultaneous inactivation of the murine homeobox genes Dlx5 and Dlx6 results in the transformation of the lower jaw into an upper jaw and in symmetry of the snout. This is the first homeotic‐like transformation found in this Hox‐free region after gene inactivation. A suggestive parallel comes from… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Dlx5 regulates regional development of the branchial arches and sensory capsules.
  • 351
  • PDF
Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus.
  • 212
Homeotic transformation of branchial arch identity after Hoxa2 overexpression.
  • 191
  • PDF
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny.
  • 662
  • PDF
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.
  • 423
  • PDF
...
1
2
3
...