Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria.

@article{Rotem2005JasmonatesNA,
  title={Jasmonates: novel anticancer agents acting directly and selectively on human cancer cell mitochondria.},
  author={Ronit Rotem and Alina Heyfets and Orit Fingrut and Dorit Blickstein and Matitiahu Shaklai and Eliezer Flescher},
  journal={Cancer research},
  year={2005},
  volume={65 5},
  pages={
          1984-93
        }
}
We reported previously that jasmonates can kill human cancer cells. Many chemotherapeutic drugs induce mitochondrial membrane permeability transition, membrane depolarization, osmotic swelling, and release of cytochrome c, involving the opening of the permeability transition pore complex (PTPC). Because jasmonates exert their cytotoxic effects independent of transcription, translation, and p53 expression, we hypothesized that these compounds may act directly on mitochondria. Mitochondrial… 

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